The Stanford Venture Technology Program is one of the best source of info I know about start-ups. In one of their recent newsletter, they mention a video of Vinod Khosla (a co-founder of Sun Microsystems and former venture capitalist with Kleiner Perkins). STVP summarizes his views as follows:

“Launching a start-up is not a rational act. And Vinod Khosla, a partner in Kleiner, Perkins, Caufield & Byers and former Sun Microsystems CEO, believes that success only comes from those who are foolish enough to think unreasonably. Entrepreneurs need to stretch themselves beyond convention and constraint to reach something extraordinary.”